Use information from this link:


These major highways serve southwest Indiana:

  • Interstate 64 – East-west access to Louisville, Kentucky, and St. Louis Missouri; plus Interstate connections in all directions
  • Interstate 69 – Connects Interstate 64 and Indiana 57 to U.S. 41 near Evansville, Indiana and presently extends to Indianapolis, Indiana.
  • U.S. 41 – 4-lane access to Chicago, Illinois, and Miami, Florida; connects to the Kentucky Parkway System; connects to Interstate 24 (Nashville, Tennessee, and Atlanta, Georgia)
  • Indiana 62 – East-west access across southern Indiana
  • Indiana 66 – Scenic east-west access along the Ohio River
  • Indiana 57 – Access to the areas northeast of the region, including part of the proposed interstate route, connecting Indiana to Canada

Download a map of the major highways in Southwest Indiana


  • Interstate 69 – Currently under construction
    • Presently extends to Indianapolis, Indiana, to Port Huron, Michigan, and the Canadian border
    • Will soon connect Evansville, Indiana to Indianapolis, Indiana
    • To the south of Evansville, Indiana, the proposed Interstate route extends to the Mexican border

Download a map of the Interstate 69 project (PDF)



Several area ports offer rail-to-water transload facilities, extensive storage areas, and a wide range of services:

View Video of Ports of Indiana – Mt. Vernon


Evansville Regional Airport offers multiple daily flights:
  • American Airlines to Chicago O’Hare International Airport (ORD)
  • American Airlines to Dallas-Fort Worth International Airport (DFW)
  • American Airlines to Charlotte (CLT)
  • Delta Connection to Hartsfield-Jackson Atlanta International Airport (ATL)
  • Delta Connection to Detroit Metropolitan Wayne County Airport (DTW)
  • United Airlines to Chicago O’Hare (ORD)
  • Allegiant Airlines to Destin-Fort Walton Beach, FL (VPS)
  • Allegiant Airlines to Orlando-Sanford, FL (SFB)

See the regular flight schedule.

Private flight service is available through Tri-State Aero.